Genomic medicine: the sorcerer's new broom?

Genomic medicine: new frontiers and new challenges.

BACKGROUND The practice of personalized medicine has made large strides since the introduction of high-throughput technologies and the vast improvements in computational biotechnology. The personalized-medicine approach to cancer management holds promise for earlier disease detection, accurate prediction of prognosis, and better treatment options; however, the early experience with personalized...

The new genomic editing system (CRISPR)

Over the past decades, progression in genetic element manipulation, and consequently, the treatment of diseases has been remarkable. It is worth noting that these genetic manipulations perform at different levels, including DNA and RNA. The earlier genomic editing techniques, including MN, ZFN , TALEN , performing their functions by creating double-stranded breaks (DSBs), and after breakage, th...

Ockham's broom: A new series

Although it is increasingly difficult to gauge what people can be expected to know, it is probably safe to assume that most readers are familiar with Ockham's razor – roughly, the principle whereby gratuitous suppositions are shaved from the interpretation of facts – enunciated by a Franciscan monk, William of Ockham, in the fourteenth century. Ockham's broom is a somewhat more recent conceit, ...

The new direction of nuclear medicine

The role of the nuclear medicine has changed, from the early days when it was the only alternative to x-rays, to the present, when nuclear images are interpreted in light of specific metabolic processes, not anatomy. The development of specific receptor targeting radiopharmaceuticals, markers of viability using PETor SPECT, analogues of neurotransmitters etc., have placed the nuclear medi...

John Broom